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Beilstein J. Org. Chem. 2016, 12, 963–968, doi:10.3762/bjoc.12.95
Graphical Abstract
Figure 1: Chemical structures of N-pentylpantothenamide (1) and of its methyl allyl derivative 2.
Figure 2: Structure of Grubbs’ catalysts used in this study.
Scheme 1: From (R)-malic acid to allyl derivatives 8 and 9 tested in cross-metathesis. Details are provided i...
Scheme 2: Synthesis of compounds 10c and 10d.
Scheme 3: Synthesis of 16.
Figure 3: In vitro antiplasmodial activity of compound 16 in growth medium containing pantetheinase (open sym...